Data Scientist Fellow — Multi-Omics Analysis

<div style="font-size:10pt;font-family:'Tahoma'">(ID: 2026-3889)<p></p><br> <p><strong>Axle</strong> is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).</p> </div><br> <div style="font-size: 10pt; font-family: 'Tahoma'"> <p><strong>Benefits We Offer:</strong></p> <ul> <li>100% Medical, Dental &amp; Vision Coverage for Employees</li> <li>Paid Time Off and Paid Holidays</li> <li>401K match up to 5%</li> <li>Educational Benefits for Career Growth</li> <li>Employee Referral Bonus</li> <li> Flexible Spending Accounts: <ul> <li>Healthcare (FSA)</li> <li>Parking Reimbursement Account (PRK)</li> <li>Dependent Care Assistant Program (DCAP)</li> <li>Transportation Reimbursement Account (TRN)</li> </ul> </li> </ul> </div> <div class="ck-content" data-wrapper="true" style=" font-family: Tahoma; font-size: 10pt;"><p style="margin: 0; text-align: start;" data-pm-slice="1 1 []"><strong>Position Overview</strong></p><p style="margin: 0; text-align: start;">&nbsp;</p><p style="margin: 0; text-align: start;"><span style="background-color:rgb(255,255,255);color:rgb(0,0,0);font-family:Tahoma;font-size:10pt;"><span class="NormalTextRun SCXW40460306 BCX8" style="font-style:normal;font-weight:400;letter-spacing:normal;margin:0px;padding:0px;text-align:justify;white-space:pre-wrap;word-spacing:0px;">The Bioinformatics Fellow for Multi-Omics Analysis will conduct comprehensive analyses of multi-omics data generated from organoid systems and corresponding normal tissues. The incumbent will characterize organoid fidelity, identify biomarkers of successful differentiation, and develop computational frameworks for organoid quality assessment, while gaining substantive training in integrative analysis of single-cell and multi-omics data. The work is central to the SOM Center’s research objectives, and the position is intended to prepare the Fellow for an independent research career in academia, government, or industry.</span></span></p><p style="margin: 0; text-align: start;">&nbsp;</p><p style="margin: 0; text-align: start;"><span style="font-family:Tahoma;font-size:10pt;"><strong>Key Responsibilities</strong></span></p><div style="font-family:Tahoma;font-size:10pt;"><p class="Paragraph SCXW14308725 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;">&nbsp;</span></p><ul><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="e5f86ba606c81700b2f3b155d727c32fc"><p class="Paragraph SCXW14308725 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="font-weight:bold;line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Multi-omics analysis. </span><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Analyze complex datasets including single-cell RNA sequencing, bulk RNA sequencing, proteomics, and metabolomics data from a range of organoid systems and their tissue counterparts.</span></span></p></li><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="e2347f171ceab1cac43e646143e773127"><p class="Paragraph SCXW14308725 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="font-weight:bold;line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Pipeline development. </span><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Develop and implement computational pipelines for data processing, quality control, and statistical analysis, and document them so that analyses are reproducible across the Center.</span></span></p></li><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="ef1fb1ad8e8a0800e11c8f4ba3906c351"><p class="Paragraph SCXW14308725 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="font-weight:bold;line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Benchmarking. </span><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Integrate SOM-generated data with publicly available datasets in order to benchmark organoid characteristics against normal tissue profiles.</span></span></p></li><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="ea258e7346e65e30cecbb9d984f53767a"><p class="Paragraph SCXW14308725 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="font-weight:bold;line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Method development. </span><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Develop and refine analytical approaches — including machine learning methods where appropriate — for classifying cellular states and assessing organoid quality, and contribute to standardized assessment protocols.</span></span></p></li><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="e12b4969f9babd5dec881994dac152940"><p class="Paragraph SCXW14308725 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="font-weight:bold;line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Collaboration and interpretation. </span><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Work closely with experimental teams to interpret results and guide protocol optimization, and collaborate with other computational staff on cross-modality data integration.</span></span></p></li><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="e221967bed5af961153eea0134c92be4b"><p class="Paragraph SCXW14308725 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="font-weight:bold;line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Dissemination. </span><span class="TextRun SCXW14308725 BCX8 NormalTextRun" style="line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Contribute to manuscript preparation and present findings at scientific conferences.</span></span></p></li></ul></div><ul><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="ea9159ef350ae51f6519d082e01afde65"><p style="margin: 0; text-align: start;">&nbsp;</p></li></ul><p style="margin: 0; text-align: start;"><span style="font-family:Tahoma;font-size:10pt;"><strong>Required Qualifications</strong></span></p><div style="font-family:Tahoma;font-size:10pt;"><p class="Paragraph SCXW162527308 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;">&nbsp;</span></p><ul><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="e98f749474620983e6d11a9e46c3765b6"><p class="Paragraph SCXW162527308 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW162527308 BCX8 NormalTextRun" style="font-weight:bold;line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Education. </span><span class="TextRun SCXW162527308 BCX8 NormalTextRun" style="line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Doctoral degree (PhD) in bioinformatics, computational biology, biostatistics, or a related quantitative field, completed or anticipated prior to the start of the appointment.</span></span></p></li><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="edad9b30bfcf8b3125ad18640a30a7d4d"><p class="Paragraph SCXW162527308 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW162527308 BCX8 NormalTextRun" style="font-weight:bold;line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Single-cell analysis. </span><span class="TextRun SCXW162527308 BCX8 NormalTextRun" style="line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Extensive experience with single-cell data analysis, including familiarity with tools such as Seurat, Scanpy, or comparable platforms.</span></span></p></li><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="e7869505746aee46b23b170a9c878fbd2"><p class="Paragraph SCXW162527308 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW162527308 BCX8 NormalTextRun" style="font-weight:bold;line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Programming. </span><span class="TextRun SCXW162527308 BCX8 NormalTextRun" style="line-height:20.7px;margin:0px;padding:0px;" data-contrast="auto" lang="EN-US">Strong programming proficiency in R and Python, together with experience in statistical analysis and data visualization.</span></span></p></li><li class="ck-list-marker-font-size ck-list-marker-font-family" data-list-item-id="ed6f0c09d05d5b2239e0c614cda6ba6a9"><p class="Paragraph SCXW162527308 BCX8" style="background-color: transparent; color: windowtext; font-style: normal; font-weight: normal; margin: 0px; padding: 0px; text-align: left; vertical-align: baseline;"><span style="font-family:Tahoma;font-size:10pt;"><span class="TextRun SCXW162527308